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  1. Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flare...

    Authors: Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt…

    Citation: BMC Rheumatology 2021 5:22

    Content type: Study protocol

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  2. Research on adherence interventions in rheumatology is limited by methodological issues, particularly heterogeneous outcomes. We aimed to describe researchers’ experiences with conducting interventional studie...

    Authors: Shahrzad Salmasi, Ayano Kelly, Susan J. Bartlett, Maarten de Wit, Lyn March, Allison Tong, Peter Tugwell, Kathleen Tymms, Suzanne Verstappen and Mary A. De Vera

    Citation: BMC Rheumatology 2021 5:26

    Content type: Research article

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  3. Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest...

    Authors: Michael J. Grayling, Theophile Bigirumurame, Svetlana Cherlin, Luke Ouma, Haiyan Zheng and James M. S. Wason

    Citation: BMC Rheumatology 2021 5:21

    Content type: Research article

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  4. Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study ...

    Authors: Onosi S. Ifesemen, Daniel F. McWilliams, Eamonn Ferguson, Richard Wakefield, Kehinde Akin-Akinyosoye, Deborah Wilson, Dorothy Platts, Susan Ledbury and David A. Walsh

    Citation: BMC Rheumatology 2021 5:23

    Content type: Study protocol

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  5. Patients with Systemic Lupus Erythematosus (SLE) often experience pain and other symptoms that negatively impact quality of life. Interventions that enhance the use of behavioral and cognitive coping strategie...

    Authors: Kelli D. Allen, Tyler Beauchamp, Christine Rini, Francis J. Keefe, Kim L. Bennell, Rebecca J. Cleveland, Kimberlea Grimm, Katie Huffman, David G. Hu, Andres Santana, Shruti Saxena Beem, Julie Walker and Saira Z. Sheikh

    Citation: BMC Rheumatology 2021 5:20

    Content type: Research article

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  6. Neuropsychiatric manifestations occur in up to 75% of adult systemic lupus erythematosus (SLE) patients and are one of the major causes of death in SLE patients. Cognitive dysfunction is a typical clinical fea...

    Authors: Li Lu, Wei Kong, Kangxing Zhou, Jinglei Chen, Yayi Hou, Huan Dou and Jun Liang

    Citation: BMC Rheumatology 2021 5:18

    Content type: Research article

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  7. Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been assoc...

    Authors: Hon Yan Ng, Orlee R. Guttman and Lori B. Tucker

    Citation: BMC Rheumatology 2021 5:16

    Content type: Case report

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  8. Polyarteritis nodosa is a type of vasculitis affecting medium- and small-sized arteries that has been associated with hepatitis B but does not have an established relationship with autoimmune hepatitis. Here w...

    Authors: Freda Kennedy, Rachel Kapelow, Bilge D. Kalyon, Nitzan C. Roth, Arvind Rishi and Maria-Louise Barilla-LaBarca

    Citation: BMC Rheumatology 2021 5:17

    Content type: Case report

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  9. Psoriatic arthritis (PsA) presents a unique clinical challenge. Affecting joints, skin, nails, and other organs, it is associated with various comorbidities and has a significant impact on quality of life, soc...

    Authors: Gareth T. Jones, Gary J. Macfarlane, Karen Forrest Keenan, Paul McNamee, Aileen R. Neilson, Stefan Siebert, A. David Burden, Lesley Kay and Philip S. Helliwell

    Citation: BMC Rheumatology 2021 5:19

    Content type: Study protocol

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  10. Fibromyalgia is characterized by chronic widespread pain, and more than half of patients with fibromyalgia report that weather-related variables aggravate their symptoms. However, the differences in actual sym...

    Authors: Kazuhiro Hayashi, Kenji Miki, Noriyuki Hayashi, Ryota Hashimoto and Masao Yukioka

    Citation: BMC Rheumatology 2021 5:14

    Content type: Research article

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  11. The self-reported Health Assessment Questionnaire (HAQ) is specifically designed to assess disability in arthritic patients. In many studies women report higher functional disability than men. The reasons for ...

    Authors: Sidona-Valentina Bala, Maria L. E. Andersson, Kristina Forslind, Björn Svensson and Ingiäld Hafström

    Citation: BMC Rheumatology 2021 5:13

    Content type: Research article

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  12. Adult onset Still’s disease (AOSD) is a rare inflammatory disorder that classically presents with high spiking fevers, evanescent rash, and arthritis. The diagnosis is one of exclusion and can be further compl...

    Authors: Arash Mollaeian, Jingjing Chen, Nina N. Chan, Gregory A. Nizialek and Christopher J. Haas

    Citation: BMC Rheumatology 2021 5:12

    Content type: Case report

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    The Correction to this article has been published in BMC Rheumatology 2021 5:29

  13. Patients with idiopathic inflammatory myopathy and autoantibodies directed against melanoma differentiation-associated protein 5 (MDA5) characteristically have interstitial lung disease, severe cutaneous invol...

    Authors: Meghan E. Ryan, Daniel Cortez, Kelly R. Dietz, Peter Karachunski and Bryce A. Binstadt

    Citation: BMC Rheumatology 2021 5:8

    Content type: Case report

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  14. B cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of approximately 98% of patients with SLE. Spleen tyrosine ki...

    Authors: Christopher W. Pohlmeyer, Ching Shang, Pei Han, Zhi-Hua Cui, Randall M. Jones, Astrid S. Clarke, Bernard P. Murray, David A. Lopez, David W. Newstrom, M. David Inzunza, Franziska G. Matzkies, Kevin S. Currie and Julie A. Di Paolo

    Citation: BMC Rheumatology 2021 5:15

    Content type: Research article

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  15. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, ulcerative neutrophilic dermatosis. In many cases, PG is associated with a wide variety of different disorders but SLE in association with PG is relatively...

    Authors: Sing Chiek Teoh, Chun Yang Sim, Seow Lin Chuah, Victoria Kok and Cheng Lay Teh

    Citation: BMC Rheumatology 2021 5:7

    Content type: Case report

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  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ruth E. Costello, Antonia Marsden, Mohammad Movahedi, Mark Lunt, Jenny H. Humphreys, Richard Emsley and William G. Dixon

    Citation: BMC Rheumatology 2021 5:11

    Content type: Correction

    Published on:

    The original article was published in BMC Rheumatology 2020 4:4

  17. Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include d...

    Authors: Miguel A. Jara-Palacios, William Chun and Nomi L. Traub

    Citation: BMC Rheumatology 2021 5:5

    Content type: Case report

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  18. Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in t...

    Authors: Ernest Choy, Lara Groves, Daniel Sugrue, Michael Hurst, John Houghton, Srinivasan Venkatachalam, Yusuf I. Patel, James R. Maxwell, Kevin G. Pollock and Sadie Henning

    Citation: BMC Rheumatology 2021 5:3

    Content type: Research article

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  19. Fictional portrayals of illness and medical management in film and television can reflect and perpetuate cultural stereotypes about illness. The aim of this study was to analyse fictional depictions of gout in...

    Authors: Christina Derksen, Rachel Murdoch, Keith J. Petrie and Nicola Dalbeth

    Citation: BMC Rheumatology 2021 5:4

    Content type: Research article

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  20. The diagnosis of Behçet disease (BD) is challenging in many cases. The purpose of this study was to describe the clinical characteristics of patients at a referral BD clinic.

    Authors: Mina Kiafar, Seyedeh Tahereh Faezi, Amir Kasaeian, Azarakhsh Baghdadi, Sahar Kakaei, Seyed Ali Mousavi, Mohammad Nejadhosseinian, Farhad Shahram, Seyedeh Zahra Ghodsi, Hormoz Shams and Fereydoun Davatchi

    Citation: BMC Rheumatology 2021 5:2

    Content type: Research article

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  21. The activation of antigen specific T cells during an immune response is a tightly regulated process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory receptor or checkpoint i...

    Authors: Mary Canavan, Achilleas Floudas, Douglas J. Veale and Ursula Fearon

    Citation: BMC Rheumatology 2021 5:1

    Content type: Review

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  22. Rheumatoid arthritis (RA) is characterized by systemic inflammation and bone and muscle loss. Recent research showed that obesity facilitates inflammation, but it is unknown if obesity also increases the risk ...

    Authors: Andreas Friedberger, Camille Figueiredo, Tobias Bäuerle, Georg Schett and Klaus Engelke

    Citation: BMC Rheumatology 2020 4:72

    Content type: Research article

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  23. Pain is the clinical hallmark of patients in patients with autoinflammatory diseases (AID) caused by variants of the NLRP3-, MEFV- or TNFRSF1A gene. However, no systematical analysis of the clinical and psycholog...

    Authors: Elisabeth Mulazzani, Nicole Zolyniak, Elisabeth Noe, Matthias Mulazzani, Shahnaz Christina Azad, Tania Kümpfel and Eduard Kraft

    Citation: BMC Rheumatology 2020 4:71

    Content type: Research article

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  24. Nationally representative data on burden of musculoskeletal conditions (MSK) in Bangladesh are not available. The objective of this study was to determine the prevalence of MSK conditions and related disabilit...

    Authors: Ahmad Zahid-Al-Quadir, M. Mostafa Zaman, Shamim Ahmed, Mahfuzur Rahman Bhuiyan, Md Mujibur Rahman, Ismail Patwary, Bidhu Bhushan Das, Shaikh Amir Hossain, Sujat Paul, Abu Shahin, Moshiur Rahman and Syed Atiqul Haq

    Citation: BMC Rheumatology 2020 4:69

    Content type: Research article

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  25. Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). Some reports have demonstrated RPGN with the sequ...

    Authors: Mikiya Kato, Risa Wakiya, Tomohiro Kameda, Kousuke Inoue, Tadashi Sofue, Yusuke Ushio, Koichi Sugihara, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Norimitsu Kadowaki and Hiroaki Dobashi

    Citation: BMC Rheumatology 2020 4:68

    Content type: Case report

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  26. Takayasu’s arteritis (TA) is a granulomatous, large vessel vasculitis with a preponderance for young women. The inflammation results in disruption of the arterial endothelium causing stenosis, endoluminal thro...

    Authors: Shania Niromi Gunasekera, Chirath Madurapperuma, Nilusha Weerasooriya, Harindra Karunathilake and Ananda Jayanaga

    Citation: BMC Rheumatology 2020 4:66

    Content type: Case report

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  27. Patients with rheumatoid arthritis (RA) have high mortality risk and are frequently treated in intensive care units (ICUs).

    Authors: Toshifumi Fujiwara, Kentaro Tokuda, Kenta Momii, Kyohei Shiomoto, Hidetoshi Tsushima, Yukio Akasaki, Satoshi Ikemura, Jun-ichi Fukushi, Jun Maki, Noriyuki Kaku, Tomohiko Akahoshi, Tomoaki Taguchi and Yasuharu Nakashima

    Citation: BMC Rheumatology 2020 4:64

    Content type: Research article

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  28. Vascular cell adhesion molecule-1 (VCAM-1) is involved in the progression of glomerular and tubulointerstitial injury in lupus nephritis (LN) and can be easily assessed in urine. The aim of this study was to a...

    Authors: Andrese Aline Gasparin, Nicole Pamplona Bueno de Andrade, Vanessa Hax, Penélope Esther Palominos, Marina Siebert, Romulo Marx, Pedro Guilherme Schaefer, Francisco Veríssimo Veronese and Odirlei André Monticielo

    Citation: BMC Rheumatology 2020 4:67

    Content type: Research article

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  29. Reddit is a highly visited social news and discussion website where individuals anonymously ask questions, post opinions and share experiences, which provide a valuable pool of publicly available data. Our obj...

    Authors: Jamie Y. E. Park, Alyssa M. Howren, Eileen Davidson and Mary A. De Vera

    Citation: BMC Rheumatology 2020 4:62

    Content type: Research article

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  30. The mixed cryoglobulinemia (MC) syndrome is a systemic inflammatory syndrome that causes small-to-medium vessel vasculitis due to cryoglobulin-containing immune complexes most commonly caused by chronic hepati...

    Authors: Nasam Alfraji, Vandan D. Upadhyaya, Christopher Bekampis and Halyna Kuzyshyn

    Citation: BMC Rheumatology 2020 4:58

    Content type: Case report

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  31. The objectives of this study were to describe the profile of ankylosing spondylitis (AS) patients treated with either infliximab (IFX) or subcutaneous golimumab (GLM) treatment in Canadian routine care setting...

    Authors: Proton Rahman, Michael Starr, Derek Haaland, Louis Bessette, Michelle Teo, Emmanouil Rampakakis, Allen J. Lehman and Francois Nantel

    Citation: BMC Rheumatology 2020 4:56

    Content type: Research article

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  32. Psoriasis is a chronic inflammatory disease of the skin affecting 2–3% of UK population. 30% of people affected by psoriasis will develop a distinct form of arthritis within 10 years of the skin condition onse...

    Authors: Jesus Miguens Blanco, Federica Borghese, Neil McHugh, Peter Kelleher, Raj Sengupta, Julian R. Marchesi and Sonya Abraham

    Citation: BMC Rheumatology 2020 4:60

    Content type: Study protocol

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  33. The B cell chemoattractant CXCL13 is a promising biomarker in rheumatoid arthritis (RA), with a plausible role in supporting diagnosis, monitoring disease activity and as a prognostic value. It is a key chemok...

    Authors: Katie Bechman, Anthony Dalrymple, Charles Southey-Bassols, Andrew P. Cope and James B. Galloway

    Citation: BMC Rheumatology 2020 4:70

    Content type: Research article

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  34. Different proportions of musculoskeletal or autoimmune manifestations associated with COVID-19 have been reported in literature. We performed a systematic review and meta-analysis with the aim of assessing the...

    Authors: Jacopo Ciaffi, Riccardo Meliconi, Piero Ruscitti, Onorina Berardicurti, Roberto Giacomelli and Francesco Ursini

    Citation: BMC Rheumatology 2020 4:65

    Content type: Research article

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  35. Access to multidisciplinary pain treatment facilities (MPTF) is limited by extensive waiting time in many countries. However, there is a lack of knowledge about the impact of waiting time on clinical outcomes,...

    Authors: Simon Deslauriers, Jean-Sébastien Roy, Sasha Bernatsky, Debbie E. Feldman, Anne Marie Pinard, François Desmeules, Mary-Ann Fitzcharles and Kadija Perreault

    Citation: BMC Rheumatology 2020 4:59

    Content type: Research article

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  36. Many patients with rheumatoid arthritis (RA) do not attain remission/low disease activity, remaining in a moderate disease activity state (MDAS) with ongoing disability and impaired quality of life (QoL). If p...

    Authors: Ian C. Scott, Julie Mount, Jane Barry and Bruce Kirkham

    Citation: BMC Rheumatology 2020 4:63

    Content type: Research article

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  37. South Asians have a higher risk of cardiovascular disease (CVD). Rheumatoid arthritis (RA) increases the risk of premature atherosclerosis. We investigated whether there was a substantial difference in the lev...

    Authors: Kanta Kumar, Suvrat Arya, Peter Nightingale, Tom Sheeran and Amita Aggarwal

    Citation: BMC Rheumatology 2020 4:57

    Content type: Research article

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  38. Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in the management of rheumatoid arthritis (RA) patients. This study evaluated tofacitin...

    Authors: Amir A. Razmjou, Jenny Brook, David Elashoff, Gurjit Kaeley, Soo Choi, Tanaz Kermani and Veena K. Ranganath

    Citation: BMC Rheumatology 2020 4:55

    Content type: Research article

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  39. A large number of patients with RA do not adhere to the recommended levels of physical activity to enhance health. According to EULAR recommendations, physical activity should be part of standard care in peopl...

    Authors: Ann Bremander, Karina Malm and Maria L. Andersson

    Citation: BMC Rheumatology 2020 4:53

    Content type: Research article

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  40. Blood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associat...

    Authors: Shefa M. Tawalbeh, Wilfredo Marin, Gabrielle A. Morgan, Utkarsh J. Dang, Yetrib Hathout and Lauren M. Pachman

    Citation: BMC Rheumatology 2020 4:52

    Content type: Research article

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  41. The idiopathic inflammatory myopathies (IIMs) are chronic autoimmune conditions, typically resulting in proximal muscle weakness and impacting upon quality of life. Accurate measurement of IIM disease activity...

    Authors: Alexander Oldroyd, William Dixon, Hector Chinoy and Kelly Howells

    Citation: BMC Rheumatology 2020 4:47

    Content type: Research article

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  42. Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those in randomized clinical trials. The objectives are to describe the profile of rheumato...

    Authors: Proton Rahman, Philip Baer, Ed Keystone, Denis Choquette, Carter Thorne, Boulos Haraoui, Andrew Chow, Rafat Faraawi, Wojciech Olszynski, John Kelsall, Emmanouil Rampakakis, Allen J. Lehman and Francois Nantel

    Citation: BMC Rheumatology 2020 4:46

    Content type: Research article

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