Articles

The impact of COVID-19 on self-management behaviours and healthcare access for people with inflammatory arthritis

Inflammatory arthritis (IA) patients have been identified as at greater risk of severe illness from COVID-19. It is likely that lockdown restrictions (enforced by the UK government in response to the COVID-19 ...

Authors: Emma Caton, Hema Chaplin, Lewis Carpenter, Melissa Sweeney, Hsiu Yen Tung, Savia de Souza, James Galloway, Elena Nikiphorou and Sam Norton

The frequency of Raynaud’s phenomenon, very early diagnosis of systemic sclerosis, and systemic sclerosis in a large Veteran Health Administration database

We describe Raynauds phenomenon (RP), potential very early diagnosis of systemic sclerosis (VEDOSS), and systemic sclerosis (SSc) in Veterans deployed in support of Post-9/11 operations. We sought to describe ...

Authors: Tracy M. Frech, Maureen A. Murtaugh, Megan Amuan and Mary Jo Pugh

Inflammatory arthritis complicating galactosialidosis: a case report

Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism. We report, for the first time, the case of a child affec...

Authors: F. Verkuil, A. M. Bosch, P. A. A. Struijs, R. Hemke and J. M. van den Berg

The fast-track outpatient clinic significantly decreases hospitalisation rates among polymyalgia rheumatica patients

This study aimed to investigate the hospitalisation rates and the reasons for hospitalisation in patients with polymyalgia rheumatica (PMR). Furthermore, it aimed to clarify the impact of a newly established F...

Authors: Stavros Chrysidis, Philip Rask Lage-Hansen, Nikoletta Svendsen and Andreas P. Diamantopoulos

Retinopathy in newly-diagnosed systemic lupus erythematosus: should we screen for ocular involvement?

Ocular manifestations are common in systemic lupus erythematosus (SLE). Retinopathy has previously been linked to disease severity and might have a significant impact on the patient’s quality of life and has a...

Authors: Hamidreza Bashiri, Nooshin Karimi, Shayan Mostafaei, Azarakhsh Baghdadi, Mohammad Nejadhosseinian and Seyedeh Tahereh Faezi

Adult onset Still’s disease in a patient with scleroderma: case report

Scleroderma and adult onset Still’s disease (AOSD) are both uncommon autoimmune disorders. These two disorders have rarely been documented to occur simultaneously. In fact, after a thorough literature review, ...

Authors: Jeffrey D. Brow, Daisy Zhu and Barbara E. Drevlow

Ixekizumab improves sleep and work productivity in patients with non-radiographic axial spondyloarthritis: results from the COAST-X trial at 52 weeks

Patients with non-radiographic axial spondyloarthritis experience negative impacts on sleep, work productivity, and activity impairment. Ixekizumab, a monoclonal antibody selectively targeting interleukin-17A,...

Authors: Atul Deodhar, Philip Mease, Helena Marzo-Ortega, Theresa Hunter, David Sandoval, Andris Kronbergs, Steven Lauzon, Ann Leung and Victoria Navarro-Compán

Ixekizumab improves spinal pain, function, fatigue, stiffness, and sleep in radiographic axial Spondyloarthritis: COAST-V/W 52-week results

This analysis assessed improvements in patients with radiographic axial spondyloarthritis (r-axSpA) treated with ixekizumab in the Assessment of Spondyloarthritis International Society (ASAS) treatment respons...

Authors: Atul A. Deodhar, Philip J. Mease, Proton Rahman, Victoria Navarro-Compán, Vibeke Strand, Theresa Hunter, Rebecca Bolce, Luis Leon, Steve Lauzon and Helena Marzo-Ortega

Variation in serum urate levels in the absence of gout and urate lowering therapy

Previous studies have noted significant variation in serum urate (sUA) levels, and it is unknown how this influences the accuracy of hyperuricemia classification based on single data points. Despite this known...

Authors: Andrew Shaffer, Elizabeth Rahn, Kenneth Saag, Amy Mudano and Angelo Gaffo

Recurrent atelectasis and brain infarction in a patient with anti-neutrophil antibody negative eosinophilic granulomatosis with polyangiitis: a case report

Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophil antibody (ANCA)-associated necrotizing vasculitis, which predominantly affects small to medium vessels, and is associated with asthma ...

Authors: Ken-ei Sada, Atsushi Miyauchi, Daisuke Hashimoto, Riku Ino, Shigeru Nojima, Shingo Yamanaka and Masafumi Kawamura

Physical activity in patients with axial spondyloarthritis in a multi-ethnic south-east Asian country

Patients with axial spondyloarthritis (axSpA) may experience spinal stiffness and pain, leading to reduced physical function and quality of life. Despite the benefits of physical activity (PA) and exercise, pr...

Authors: Jie Kie Phang, Andrew Yu Keat Khor, Yu Heng Kwan, Chin Teck Ng and Warren Fong

Cardiovascular disease risk calculators to reflect the subclinical atherosclerosis of coronary artery in rheumatoid arthritis: a pilot study

Cardiovascular diseases (CVDs) are the leading cause of death in patients with rheumatoid arthritis (RA). Coronary artery calcium (CAC) score quantifies the severity of atherosclerosis. We estimated CVD risk u...

Authors: Se Hee Kim, Sang-Heon Lee, Hae-Rim Kim and Hong Ki Min

Longitudinal development of incident gout from low-normal baseline serum urate concentrations: individual participant data analysis

Elevated serum urate (SU) concentration is the central risk factor for the development of gout. The aim of this study was to examine the incidence of gout in people with low and normal SU levels (< 7.00 mg/dL).

Authors: Philip C. Robinson, Christopher Frampton, Amanda Phipps-Green, Tuhina Neogi, Lisa Stamp, William Taylor, Tony R. Merriman and Nicola Dalbeth

Sleep disorders and gout in Australian adults

The aims of our study were two-fold. Firstly, to determine if there is an association between gout and OSA in a representative Australian adult population. Secondly, to explore associations between gout and pa...

Authors: Julia New-Tolley, Amy C. Reynolds, Sarah L. Appleton, Tiffany K. Gill, Susan Lester, Robert J. Adams and Catherine L. Hill

No association between rheumatoid arthritis and cognitive impairment in a cross-sectional national sample of older U.S. adults

Studies suggest an increased prevalence of cognitive impairment (CI) among people with rheumatoid arthritis (RA). However, most prior studies have used convenience samples which are subject to selection biases...

Authors: Michael J. Booth, Mary R. Janevic, Lindsay C. Kobayashi, Daniel J. Clauw and John D. Piette

Coronary artery aneurysms in children is not always Kawasaki disease: a case report on Takayasu arteritis

Coronary artery (CA) aneurysms in children are a rare but potentially life-threatening finding and are highly associated with Kawasaki disease (KD).

Authors: Michelle Lee, Esra Meidan, MaryBeth Son, Audrey Dionne, Jane W. Newburger and Kevin G. Friedman

Dissociation between 2-[¹⁸F]fluoro-2-deoxy-D-glucose positron emission computed tomography, ultrasound and clinical assessments in patients with non-severe rheumatoid arthritis, including remission

Inflammation of patients joints with severe disease activity of rheumatoid arthritis (RA) has already been visualized and quantified by 2-[¹⁸F]fluoro-2-deoxy-D-glucose positron emission computed tomography ([¹⁸F]...

Authors: Charline Rinkin, Pacôme Fosse, Olivier Malaise, Nathalie Chapelier, Jil Horrion, Laurence Seidel, Adelin Albert, Roland Hustinx and Michel G. Malaise

The Joint Vasculitis Registry in German-speaking countries (GeVas) – a prospective, multicenter registry for the follow-up of long-term outcomes in vasculitis

Vasculitides comprise a group of rare diseases which affect less than 5 in 10.000 individuals. Most types of vasculitis can become organ- and life-threatening and are characterized by chronicity, high morbidit...

Authors: Christof Iking-Konert, Pia Wallmeier, Sabrina Arnold, Sabine Adler, Kirsten de Groot, Bernhard Hellmich, Bimba F. Hoyer, Konstanze Holl-Ulrich, Gabriele Ihorst, Margit Kaufmann, Ina Kötter, Ulf Müller-Ladner, T. Magnus, Jürgen Rech, Fabian Schubach, Hendrik Schulze-Koops…

Relation of therapies for ankylosing spondylitis and psoriatic arthritis to risk of myocardial infarction: a nested case control study

Risk of myocardial infarction (MI) is elevated in ankylosing spondylitis and psoriatic arthritis (AS/PsA) compared to the general population. We evaluated the risk of MI related to the use of tumor necrosis fa...

Authors: Rachael Stovall, Christine Peloquin, David Felson, Tuhina Neogi and Maureen Dubreuil

Mechanic’s hand; is it a prodromic sign of disease relapse of anti-synthetase syndrome; a case report

Anti-synthetase syndrome is the collection of myositis and/or interstitial lung disease with the presence of various antibodies directed against an aminoacyl transfer RNA synthetase. Anti Jo − 1 antibody is th...

Authors: C. T. Rosa, A. S. Thilakarathne, L. A. Senevirathne, A. Wijeyeratna and D. Munidasa

BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study

Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flare...

Authors: Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt…

Researchers’ perspectives on methodological challenges and outcomes selection in interventional studies targeting medication adherence in rheumatic diseases: an OMERACT-adherence study

Research on adherence interventions in rheumatology is limited by methodological issues, particularly heterogeneous outcomes. We aimed to describe researchers’ experiences with conducting interventional studie...

Authors: Shahrzad Salmasi, Ayano Kelly, Susan J. Bartlett, Maarten de Wit, Lyn March, Allison Tong, Peter Tugwell, Kathleen Tymms, Suzanne Verstappen and Mary A. De Vera

Innovative trial approaches in immune-mediated inflammatory diseases: current use and future potential

Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest...

Authors: Michael J. Grayling, Theophile Bigirumurame, Svetlana Cherlin, Luke Ouma, Haiyan Zheng and James M. S. Wason

Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study

Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study ...

Authors: Onosi S. Ifesemen, Daniel F. McWilliams, Eamonn Ferguson, Richard Wakefield, Kehinde Akin-Akinyosoye, Deborah Wilson, Dorothy Platts, Susan Ledbury and David A. Walsh

Pilot study of an internet-based pain coping skills training program for patients with systemic Lupus Erythematosus

Patients with Systemic Lupus Erythematosus (SLE) often experience pain and other symptoms that negatively impact quality of life. Interventions that enhance the use of behavioral and cognitive coping strategie...

Authors: Kelli D. Allen, Tyler Beauchamp, Christine Rini, Francis J. Keefe, Kim L. Bennell, Rebecca J. Cleveland, Kimberlea Grimm, Katie Huffman, David G. Hu, Andres Santana, Shruti Saxena Beem, Julie Walker and Saira Z. Sheikh

Association of lipoproteins and thyroid hormones with cognitive dysfunction in patients with systemic lupus erythematosus

Neuropsychiatric manifestations occur in up to 75% of adult systemic lupus erythematosus (SLE) patients and are one of the major causes of death in SLE patients. Cognitive dysfunction is a typical clinical fea...

Authors: Li Lu, Wei Kong, Kangxing Zhou, Jinglei Chen, Yayi Hou, Huan Dou and Jun Liang

Chronic recurrent multifocal osteomyelitis and primary sclerosing cholangitis with type 1 autoimmune hepatitis in a child with ulcerative colitis: a case report

Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been assoc...

Authors: Hon Yan Ng, Orlee R. Guttman and Lori B. Tucker

A rare case of Polyarteritis Nodosa associated with autoimmune hepatitis: a case report

Polyarteritis nodosa is a type of vasculitis affecting medium- and small-sized arteries that has been associated with hepatitis B but does not have an established relationship with autoimmune hepatitis. Here w...

Authors: Freda Kennedy, Rachel Kapelow, Bilge D. Kalyon, Nitzan C. Roth, Arvind Rishi and Maria-Louise Barilla-LaBarca

Correction to: Adult onset Still’s disease in the elderly: a case-based literature review

Authors: Arash Mollaeian, Jingjing Chen, Nina N. Chan, Gregory A. Nizialek and Christopher J. Haas

The BSR-PsA: study protocol for the British Society for Rheumatology psoriatic arthritis register

Psoriatic arthritis (PsA) presents a unique clinical challenge. Affecting joints, skin, nails, and other organs, it is associated with various comorbidities and has a significant impact on quality of life, soc...

Authors: Gareth T. Jones, Gary J. Macfarlane, Karen Forrest Keenan, Paul McNamee, Aileen R. Neilson, Stefan Siebert, A. David Burden, Lesley Kay and Philip S. Helliwell

Weather sensitivity associated with quality of life in patients with fibromyalgia

Fibromyalgia is characterized by chronic widespread pain, and more than half of patients with fibromyalgia report that weather-related variables aggravate their symptoms. However, the differences in actual sym...

Authors: Kazuhiro Hayashi, Kenji Miki, Noriyuki Hayashi, Ryota Hashimoto and Masao Yukioka

Reported disability in relation to observed activity limitation, grip strength and physical function in women and men with rheumatoid arthritis

The self-reported Health Assessment Questionnaire (HAQ) is specifically designed to assess disability in arthritic patients. In many studies women report higher functional disability than men. The reasons for ...

Authors: Sidona-Valentina Bala, Maria L. E. Andersson, Kristina Forslind, Björn Svensson and Ingiäld Hafström

Adult onset Still’s disease in the elderly: a case-based literature review

Adult onset Still’s disease (AOSD) is a rare inflammatory disorder that classically presents with high spiking fevers, evanescent rash, and arthritis. The diagnosis is one of exclusion and can be further compl...

Authors: Arash Mollaeian, Jingjing Chen, Nina N. Chan, Gregory A. Nizialek and Christopher J. Haas

More than meets the naked eye: an unusual psoriatic arthritis mimicry and the important role of dermoscopic examination

Psoriatic arthritis (PsA) can manifest in various forms. This includes mimicry of other diseases. We describe an unusual mimicry of PsA.

Authors: Lim Jo Anne, Mohd Jazman Che Rahim, Wan Syamimee Wan Ghazali, Wan Aireene Wan Ahmed and Seoparjoo Azmel Mohd Isa

Anti-MDA5 juvenile idiopathic inflammatory myopathy with second-degree heart block but no skin or lung involvement: a case report

Patients with idiopathic inflammatory myopathy and autoantibodies directed against melanoma differentiation-associated protein 5 (MDA5) characteristically have interstitial lung disease, severe cutaneous invol...

Authors: Meghan E. Ryan, Daniel Cortez, Kelly R. Dietz, Peter Karachunski and Bryce A. Binstadt

Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis

B cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of approximately 98% of patients with SLE. Spleen tyrosine ki...

Authors: Christopher W. Pohlmeyer, Ching Shang, Pei Han, Zhi-Hua Cui, Randall M. Jones, Astrid S. Clarke, Bernard P. Murray, David A. Lopez, David W. Newstrom, M. David Inzunza, Franziska G. Matzkies, Kevin S. Currie and Julie A. Di Paolo

Capillaroscopy as a diagnostic tool in the diagnosis of mixed connective tissue disease (MCTD): a case report

The concept of mixed connective tissue disease (MCTD) as a unique connective tissue disease has endured for half a century. Disease onset can be in adulthood (MCTD) or of juvenile onset (jMCTD) and is characte...

Authors: Mislav Radić and Rebecca S. Overbury

Pyoderma gangrenosum and cobalamin deficiency in systemic lupus erythematosus: a rare but non fortuitous association

Pyoderma gangrenosum (PG) is an uncommon, idiopathic, ulcerative neutrophilic dermatosis. In many cases, PG is associated with a wide variety of different disorders but SLE in association with PG is relatively...

Authors: Sing Chiek Teoh, Chun Yang Sim, Seow Lin Chuah, Victoria Kok and Cheng Lay Teh

Correction to: The effect of glucocorticoid therapy on mortality in patients with rheumatoid arthritis and concomitant type II diabetes: a retrospective cohort study

An amendment to this paper has been published and can be accessed via the original article.

Authors: Ruth E. Costello, Antonia Marsden, Mohammad Movahedi, Mark Lunt, Jenny H. Humphreys, Richard Emsley and William G. Dixon

Resolution of calcinosis using bisphosphonates in overlap syndrome – a case report

Calcinosis cutis is a common complication of pediatric rheumatologic diseases. However, there is currently no consensus on first-line treatment. Bisphosphonates have been described as a successful treatment in...

Authors: Mitchell Platter, Brian Pugmire and Reshma Patel

Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report

Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include d...

Authors: Miguel A. Jara-Palacios, William Chun and Nomi L. Traub

Outcomes in rheumatoid arthritis patients treated with abatacept: a UK multi-centre observational study

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in t...

Authors: Ernest Choy, Lara Groves, Daniel Sugrue, Michael Hurst, John Houghton, Srinivasan Venkatachalam, Yusuf I. Patel, James R. Maxwell, Kevin G. Pollock and Sadie Henning

“An apple pie a day does not keep the doctor away”: Fictional depictions of gout in contemporary film and television

Fictional portrayals of illness and medical management in film and television can reflect and perpetuate cultural stereotypes about illness. The aim of this study was to analyse fictional depictions of gout in...

Authors: Christina Derksen, Rachel Murdoch, Keith J. Petrie and Nicola Dalbeth

Diagnosis of Behçet’s disease: clinical characteristics, diagnostic criteria, and differential diagnoses

The diagnosis of Behçet disease (BD) is challenging in many cases. The purpose of this study was to describe the clinical characteristics of patients at a referral BD clinic.

Authors: Mina Kiafar, Seyedeh Tahereh Faezi, Amir Kasaeian, Azarakhsh Baghdadi, Sahar Kakaei, Seyed Ali Mousavi, Mohammad Nejadhosseinian, Farhad Shahram, Seyedeh Zahra Ghodsi, Hormoz Shams and Fereydoun Davatchi

The PD-1:PD-L1 axis in Inflammatory Arthritis

The activation of antigen specific T cells during an immune response is a tightly regulated process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory receptor or checkpoint i...

Authors: Mary Canavan, Achilleas Floudas, Douglas J. Veale and Ursula Fearon

A new method for quantitative assessment of hand muscle volume and fat in magnetic resonance images

Rheumatoid arthritis (RA) is characterized by systemic inflammation and bone and muscle loss. Recent research showed that obesity facilitates inflammation, but it is unknown if obesity also increases the risk ...

Authors: Andreas Friedberger, Camille Figueiredo, Tobias Bäuerle, Georg Schett and Klaus Engelke

Clinical and psychological phenomenology of pain in autoinflammatory diseases

Pain is the clinical hallmark of patients in patients with autoinflammatory diseases (AID) caused by variants of the NLRP3-, MEFV- or TNFRSF1A gene. However, no systematical analysis of the clinical and psycholog...

Authors: Elisabeth Mulazzani, Nicole Zolyniak, Elisabeth Noe, Matthias Mulazzani, Shahnaz Christina Azad, Tania Kümpfel and Eduard Kraft

Prevalence of musculoskeletal conditions and related disabilities in Bangladeshi adults: a cross-sectional national survey

Nationally representative data on burden of musculoskeletal conditions (MSK) in Bangladesh are not available. The objective of this study was to determine the prevalence of MSK conditions and related disabilit...

Authors: Ahmad Zahid-Al-Quadir, M. Mostafa Zaman, Shamim Ahmed, Mahfuzur Rahman Bhuiyan, Md Mujibur Rahman, Ismail Patwary, Bidhu Bhushan Das, Shaikh Amir Hossain, Sujat Paul, Abu Shahin, Moshiur Rahman and Syed Atiqul Haq

The development of rapidly progressive glomerulonephritis associated with both antineutrophil cytoplasmic antibody-associated vasculitis and anti-glomerular basement membrane nephritis in the course of nontuberculous mycobacterium infection: a case report

Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). Some reports have demonstrated RPGN with the sequ...

Authors: Mikiya Kato, Risa Wakiya, Tomohiro Kameda, Kousuke Inoue, Tadashi Sofue, Yusuke Ushio, Koichi Sugihara, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Norimitsu Kadowaki and Hiroaki Dobashi

A rare presentation of Takayasu’s arteritis- unilateral finger clubbing – case report

Takayasu’s arteritis (TA) is a granulomatous, large vessel vasculitis with a preponderance for young women. The inflammation results in disruption of the arterial endothelium causing stenosis, endoluminal thro...

Authors: Shania Niromi Gunasekera, Chirath Madurapperuma, Nilusha Weerasooriya, Harindra Karunathilake and Ananda Jayanaga