Skip to main content

Table 2 Comparison of immunological characteristics of patients with pSS

From: Seronegative primary Sjögren’s syndrome, a distinct subtype of primary Sjögren’s syndrome in Chinese patients

 

Seronegative pSS

(n = 40)

Seropositive pSS

(n = 192)

P-value

Low Complement 3

10/40 (25.00)

66/192 (34.40)

0.250

Low Complement 4

0/40 (0.00)

17/192 (8.90)

0.105

Gamma globulin, g/L

30.10 (26.50–35.00)

32.80 (28.95–37.95)

0.012*

Immunoglobulin A, g/L

2.47 (1.87–3.50)

2.98 (2.26–3.93)

0.027*

Immunoglobulin G, g/L

14.20 (12.20–15.70)

17.45 (13.83–21.45)

0.000*

Immunoglobulin M, g/L

1.21 (0.89–2.07)

1.17 (0.81–1.56)

0.172

ANA positivity

22/40 (55.00)

183/192 (95.30)

0.000*

RF positivity

4/40 (10.00)

50/179 (27.90)

0.017*

Anti-CCP positive

1/30 (3.30)

7/138 (5.10)

1.000

Anti-TGA positive

4/13 (30.80)

16/86 (18.60)

0.517

Anti-TPO positivity

8/13 (61.50)

26/84 (31.00)

0.066

Anti-TRAb positivity

0/7 (0.00)

5/52 (9.60)

1.000

  1. Continuous data were presented as median with 25–75th percentiles and categorical data as positive number/test number (%). ANA, anti-nuclear antibody positivity; RF, Rheumatoid factor; CCP, cyclic citrullinated peptides antibody; anti-TGA, anti-thyroglobulin antibody; anti-TPO, anti-thyroid peroxidase antibody; TRAb, thyrotrophin receptor antibody. *, P value < 0.05