Biologic versus placebo; in combination with MTX | Low disease activity, ROR (p value) | Remission, ROR (p value) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number of studies | Number of patients | DAS 28 versus CDAI | DAS 28 versus SDAI | SDAI versus CDAI | Number of studies | Number of patients | DAS 28 versus CDAI | DAS 28 versus SDAI | SDAI versus CDAI | DAS 28 versus Boolean approach | SDAI versus Boolean approach | CDAI versus Boolean approach | |
IL-6 inhibitor | |||||||||||||
Tocilizumab | 9 | 3307 | 2.90 (< 0.001) | 2.54 (< 0.001) | 1.10 (< 0.001) | 9 | 3272 | 2.86 (< 0.001) | 2.70 (< 0.001) | 1.06 (0.240) | 2.63 (< 0.001) | 1.05 (0.648) | 1.01 (0.953) |
TNFα inhibitor | |||||||||||||
Adalimumab | 12 | 4520 | 1.10 (0.045) | 1.07 (0.142) | –* | 13 | 4640 | 1.24 (0.019) | 1.14 (0.139) | –* | 1.02 (0.814) | 0.89 (0.119) | 0.82 (0.014) |
Certolizumab pegol | 6 | 2445 | 1.01 (0.952) | 1.03 (0.719) | 0.98 (0.595) | 6 | 2458 | 1.06 (0.670) | 1.13 (0.377) | 0.94 (0.160) | 1.35 (0.033) | 1.20 (0.069) | 1.29 (0.020) |
Etanercept | 3†| 877 | 0.96 (0.691) | 0.97 (0.737) | 1.00 (0.947) | 3†| 877 | 0.79 (0.284) | 0.72 (0.136) | 1.09 (0.241) | 1.05 (0.825) | 1.42 (0.044) | 1.31 (0.137) |
Golimumab | 5 | 987 | 1.03 (0.777) | 0.93 (0.495) | 1.08 (0.035) | 5 | 987 | 1.00 (0.994) | 0.92 (0.700) | 1.07 (0.436) | 0.93 (0.803) | 0.96 (0.833) | 0.93 (0.764) |
Infliximab | 1‡ | 171 | 0.65 (0.181) | 0.57 (0.083) | 1.15 (0.244) | 1‡ | 171 | 0.70 (0.696) | 0.31 (0.338) | 2.23 (0.172) | 0.50 (0.606) | 1.61 (0.678) | 0.72 (0.770) |
IL-1 receptor antagonist | |||||||||||||
Anakinra | 2‡ | 1035 | 1.42 (0.012) | 1.27 (0.080) | 1.12 (0.017) | 2‡ | 1035 | 3.40 (0.017) | 2.82 (0.046) | 1.20 (0.408) | 0.65 (0.595) | 0.23 (0.024) | 0.20 (0.015) |
T-cell activation inhibitor | |||||||||||||
Abatacept | 8 | 2363 | 1.16 (0.051) | 1.06 (0.416) | –* | 8 | 2364 | 1.01 (0.953) | 0.94 (0.687) | 0.99 (0.859) | 0.80 (0.279) | 0.81 (0.205) | 0.82 (0.227) |
B-cell depleting agent | |||||||||||||
Rituximab | 2§ | 528 | 1.38 (0.441) | 1.37 (0.423) | 1.01 (0.941) | 2§ | 534 | 0.80 (0.744) | 0.54 (0.436) | 1.52 (0.416) | 2.15 (0.164) | 3.12 (0.112) | 2.53 (0.121) |