Fig. 2

Rapid monitoring of refills of biologic disease-modifying anti-rheumatic drugs following launch of the Biosimilars Initiative. Cumulative incidence of first (A), second (B), third (C) and fourth (D) etanercept refills, first refill of an etanercept biosimilar (E), and first refill of a different (non-etanercept) biologic, biosimilar, or targeted synthetic disease-modifying anti-rheumatic drug (F) during one year of follow-up. Periods with likelihood ratios of 7.1 or higher are shaded. Likelihood ratios were not estimated during the first 31 days of follow-up due to instability in likelihood ratios caused by small numbers