Table 1 Outline Interview schedule

• Tell me what you know about RA?

• Do you ever worry about the possibility of developing RA in the future?

• What would you think if you were told that you could have a test that would tell you how likely you were to develop RA?

• What would your concerns be if you knew what your risk of developing RA was?

• What kind of tests do you think people might be able to do to work out whether or not you might develop RA (tests that are available now and tests that might become available in the future)?

• Various tests can currently be done, and various tests are currently being developed to predict the development of RA. What are your thoughts about:

 ° Blood tests looking at biomarkers, molecules in the blood

 ° Blood tests looking at genes

 ° Tests involving scanning the joints with either an ultrasound or MRI

 ° Tests involving taking tissue out of a joint or elsewhere (e.g. lymph nodes)

• What are your thoughts about taking medicines to reduce the risk of RA developing in the future?

• What are your thoughts about changing your lifestyle (e.g. stop smoking, more exercise, change diet) to reduce the risk of developing RA in the future?