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Table 1 Baseline and trend of the patient’s laboratory work-up

From: Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report

  Baseline Day 1 Day 4 Day 7 Day 13 2 months follow-up 8 months follow-up Reference range and units
WBC 5140 1450 1920 2260 13,990 10,320 7650 3500–10,500 (cells/ul)
Absolute neutrophils 2990 420 840 990 6440 7970 5550 1700–7000 cells/ul
RBC count 2760 2700 2910 3090 2810 2980 3720 3900–5030 cells/ul
Hemoglobin 9.7 9.4 9.9 10.2 8.9 9.7 11.3 12–15.5 g/dl
MCV 105 104 104 102 110 109 105 82–98 fl
Platelets 161 82 49 311 688 150 156 150–450 units/ul
Creatinine 1.17 1.65   1.06 1.01 1.09 1.58 0.5–0.9 (mg/dl)
BUN 21 65   21 22 16 33 8–23 (mg/dl)
GFR 56 37   63 67 61 39 ml/min/1.73 m2
Reticulocyte count   0.36   2.41 4.44    0.6–1.8%
Serum folate   20       5–24 (ng/ml)
Vitamin B12   127       180–914 (pg/ml)
Vitamin D,25-OH   7       30–100 (ng/ml)
LDH   426       140–271 IU/l
  1. Methylentetrahydrofolate reductase genetic test: Negative for the variants C677T and A1298C