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Table 3 Correlations between MSUS/MBDA Score and Clinical Disease Activity Measures

From: Ultrasound and multi-biomarker disease activity score for assessing and predicting clinical response to tofacitinib treatment in patients with rheumatoid arthritis

Baseline MSUS/MBDA score association with Baseline CDAI/DAS28/ESR

 

CDAI Baseline

DAS28/ESR Baseline

PDUS Baseline

0.53**

0.58**

GSUS Baseline

0.65**

0.53**

mUS7 PDUS Baseline

0.45*

0.58**

mUS7 GSUS Baseline

0.49*

0.42*

MBDA Score Baseline

0.24

0.47*

2 Week MSUS/MBDA score association with 2 Week CDAI/DAS28

 

CDAI 2 Week

DAS28/ESR 2 Week

PDUS 2 Week

0.45*

0.49*

GSUS 2 Week

0.62**

0.52**

mUS7 PDUS 2 Week

0.43*

0.49*

mUS7 GSUS 2 Week

0.41*

0.31

MBDA Score 2 Week

0.05

0.19

12 Week MSUS/MBDA score association with 12 Week CDAI/DAS28

 

CDAI 12 Week

DAS28/ESR 12 Week

PDUS 12 Week

0.38

0.54**

GSUS 12 Week

0.52**

0.53**

mUS7 PDUS 12 Week

0.28

0.43*

mUS7 GSUS 12 Week

0.49*

0.44*

MBDA Score 12 Week

−0.19

0.05

Baseline MSUS/MBDA score association with 12 Week change in CDAI/DAS28

 

CDAI (Δ 0–12 weeks)

DAS28/ESR (Δ 0–12 weeks)

PDUS Baseline

0.55**

0.45*

GSUS Baseline

0.47*

0.25

mUS7 PDUS Baseline

0.62**

0.55**

mUS7 GSUS Baseline

0.47*

0.33

MBDA Score Baseline

0.44*

0.50*

2 Week change in MSUS/MBDA score association with 12 Week change in CDAI/DAS28

 

CDAI (Δ 0–12 weeks)

DAS28/ESR (Δ 0–12 weeks)

PDUS (Δ 0–2 weeks)

0.37

0.42*

GSUS (Δ 0–2 weeks)

0.44*

0.42*

mUS7 PDUS (Δ 0–2 weeks)

0.47*

0.57**

mUS7 GSUS (Δ 0–2 weeks)

0.56**

0.51**

MBDA Score (Δ 0–2 weeks)

0.22

0.29

12 Week change in MSUS/MBDA score association with 12 Week change in CDAI/DAS28

 

CDAI (Δ 0–12 week)

DAS28/ESR (Δ 0–12 week)

PDUS (Δ 0–12 week)

0.58**

0.56**

GSUS (Δ 0–12 week)

0.47*

0.34

mUS7 PDUS (Δ 0–12 week)

0.60**

0.64**

mUS7 GSUS (Δ 0–12 week)

0.54**

0.48*

MBDA Score (Δ 0–12 week)

0.44*

0.59**

  1. *p < 0.05, **p < 0.01; PDUS Power doppler ultrasound, GSUS Gray scale ultrasound, mUS7 modified ultrasound 7, MBDA Multi-biomarker Disease activity score, CDAI Clinical disease activity index, DAS28/ESR Disease activity score/erythrocyte sedimentation rate
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BMC Rheumatology

ISSN: 2520-1026

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