Table 2 Biomarkers investigated with ELISA in sera samples of female U-JDM versus age matched female controls
From: Serum protein biomarkers for juvenile dermatomyositis: a pilot study
8 untreated JDM vs 17 healthy control females | ||||||
|---|---|---|---|---|---|---|
Biomarker Name, (Accession Number) | SomaScan® assay | MSD ELISA assay | Confirm (Yes/No) | Previously reported by others or novel | ||
Fold Change | Adjusted P-value (direction) | Fold Change | Adjusted P-value | |||
CXCL11 (I-TAC) (O14625) | 13.7 | < 0.001 (↑) | 6.75 | < 0.001 (↑) | Yes | [31] |
IL-17B (Q9UHF5) | −2.1 | < 0.001 (↓) | −2.4 | < 0.001 (↓) | Yes | Novel |
IL-17D (Q8TAD2) | −1.28 | 0.002 (↓) | −1.4 | 0.128 (↓) | No | [32] |
IL-22 (Q9GZX6) | 62 | < 0.001(↑) | 4.27 | < 0.001 (↑) | Yes | Novel |
CXCL10 (IP-10) (P02778) | 11.3 | < 0.001 (↑) | 16.4 | < 0.001 (↑) | Yes | [33] |
MCP-1 (P13500) | 2.1 | < 0.001 (↑) | 3.11 | 0.001 (↑) | Yes | [34] |
ANGPT2 (O15123) | 3.8 | < 0.001 (↑) | 2.6 | < 0.001 (↑) | Yes | Novel |
MIF (P14174) | 2.38 | < 0.001 (↑) | 1.2 | 0.467 (↑) | No | [35] |
IL-23 (P29460, Q9NPF7) | 2.22 | 0.001 (↑) | −1.1 | 0.306 (↓) | No | Novel |