Fig. 3
From: MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies
Networks of predicted targets of miR-96-5p downregulated in idiopathic inflammatory myopathy patients compared to controls QIAGEN’s Ingenuity Pathway Analysis (IPA) ‘microRNA target filter’ predicted mRNA targets of miR-96-5p which are downregulated in RNA sequencing of whole blood from (a) polymyositis (PM) (n = 7) and (b) anti-Jo1 positive PM and dermatomyositis (DM) samples (n = 5) compared to controls (n = 5). No targets were identified in the DM subgroup. Red colouring indicates upregulation, green colouring indicates downregulation and darker shades indicate greater fold change. (c) Summary of IPA microRNA target filter predicted targets. Confidence is ‘high’ if the TargetScan database cumulative weighted context ++ score (CWCS) is − 0.4 or below, indicating a predicted repression of at least 25% and ‘moderate’ if the CWCS is − 0.2 to − 0.4, indicating a predicted repression of 13–25%