Day 0 | W6 | M3 | M6 | M9 | M12 | M18 | M24 | ||
---|---|---|---|---|---|---|---|---|---|
P1 | DAS 28 | 1.76 | 3.14 | 2.43 | 2.43 | 1.76 | 1.55 | 5.18 | 1.64 |
RTI | 4 | 6 | 6 | 6 | 6 | 8 | 8 | 6 | |
Dose | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
P2 | DAS 28 | 1.69 | 2.35 | 2.79 | 2.89 | 2.69 | 3.14 | 1.34 | 2.13 |
RTI | 4 | 6 | 6 | 8 | 6 | 8 | 4 | 4 | |
Dose | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
P3 | DAS 28 | 2.4 | 2.07 | 2.57 | 3.92 | 2.14 | 3.7 | 3.68 | 2.61 |
RTI | 4 | 6 | 6 | 8 | 4 | 4 | 5 | 4 | |
Dose | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
P4 | DAS 28 | 2.6 | 1.42 | 1.34 | 1.94 | 1.05 | 1.12 | 3.35 | 1.49 |
RTI | 4 | 6 | 8 | 8 | 4 | 5 | 5 | 5 | |
Dose | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
P5 | DAS 28 | 2.58 | 2.6 | 1.61 | 2.11 | 2.23 | 2.22 | 2.03 | 0.91 |
RTI | 4 | 6 | 6 | 7 | 8 | 8 | 9 | 9 | |
Dose | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
P6 | DAS 28 | 0.48 | NA | 0.76 | 1.37 | 0.28 | 0.28 | 2.22 | 1.84 |
RTI | 4 | 6 | 7 | 6 | 6 | 6 | 8 | 9 | |
Dose | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
P 7 | DAS 28 | 1.61 | NA | 2.57 | 1.34 | 1.94 | 3.28 | 2 | 2.5 |
RTI | 4 | 5 | 8 | 8 | 8 | 8 | 8 | 8 | |
Dose | 6 | 8 | 8 | 6 | 6 | 6 | 8 | 8 | |
P8 | DAS 28 | 1.98 | 2.26 | 1.68 | 2.14 | NA | 1.81 | 2.42 | Secondary failure Switch to infliximab |
RTI | 4 | 6 | 6 | 8 | 8 | 8 | 4 | ||
Dose | 8 | 8 | 8 | 8 | 8 | 8 | 4 | ||
P9 | DAS 28 | 0.07 | 1.45 | 1.89 | 1.89 | 1.12 | 0.76 | 0.76 | 1.12 |
RTI | 4 | 6 | 6 | 7 | 7 | 8 | 9 | 10 | |
Dose | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
P10 | DAS 28 | 1.38 | 3.2 | NA | 2.85 | 2.45 | 3.71 | Secondary failure Switch to abatacept | |
RTI | 4 | 6 | 4 | 4 | 4 | 4 | |||
Dose | 8 | 8 | 8 | 8 | 8 | 8 | |||
P11 | DAS 28 | 2.31 | 2.31 | 3.48 | 0.85 | Neutropenia Switch to abatacept | |||
RTI | 4 | 5 | 6 | 4 | |||||
Dose | 4 | 4 | 6 | 6 | |||||
P12 | DAS 28 | 2.56 | 1.03 | 4.08 | 3.51 | Secondary failure Switch to abatacept | |||
RTI | 4 | 6 | 6 | 4 | |||||
Dose | 8 | 8 | 8 | 8 | |||||
P13 | DAS 28 | 0 | 1.03 | 1.55 | 2.57 | 5.35 | Secondary failure Switch to abatacept | ||
RTI | 4 | 6 | 6 | 8 | 6 | ||||
Dose | 6 | 6 | 6 | 6 | 6 |