The effect of glucocorticoid therapy on mortality in patients with rheumatoid arthritis and concomitant type II diabetes: a retrospective cohort study

Table 3 Multiplicative and additive interaction^a between diabetes mellitus and ever glucocorticoid use

Outcome	Multiplicative interaction	Additive interaction
Outcome	Hazard ratio (95% confidence interval)	RERI (95% confidence interval)	RAE (95% confidence interval)
All-cause mortality
Unadjusted	0.69 (0.51 to 0.91)	0.94 (−0.29 to 2.16)	1.27 (0.95 to 1.70)
All-cause mortality
Adjusted^b	0.86 (0.64 to 1.15)	0.41 (−0.36 to 1.18)	1.22 (0.86 to 1.72)
CV mortality
Unadjusted	0.70 (0.44 to 1.11)	0.40 (−1.19 to 2.00)	1.17 (0.64 to 2.14)
CV mortality
Adjusted^b	0.93 (0.60 to 1.48)	0.11 (−0.75 to 0.96)	1.11 (0.48 to 2.57)

^a On the multiplicative scale significant interaction is different than 1, on the additive scale significant interaction for the RERI is different than 0 and for the RAE is different than 1
^bAdjusted for age, gender, Charlson comorbidity index, baseline BMI, baseline smoking status, DMARDs, prior GC, prior macrovascular disease and NSAIDs

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