Table 3 Patient outcomes by change in HAQ-DI between month 0 and month 6
HAQ-DI-dcrit improvement (≥0.68) at month 6 (n = 639) | Small improvement (≥0.22 to < 0.68) at month 6 (n = 961) | No improvement (< 0.22) at month 6 (n = 1295) | ||||
|---|---|---|---|---|---|---|
Outcome | Month 12 | Month 24 | Month 12 | Month 24 | Month 12 | Month 24 |
n | 536 | 385 | 782 | 553 | 928 | 638 |
Mean values (standard deviation) | ||||||
DAS28 | 2.90 (1.26) | 2.86 (1.25) | 3.48 (1.33) | 3.30 (1.38) | 3.83 (1.31) | 3.62 (1.27) |
Paina | 3.1 (2.4) | 3.1 (2.5) | 4.1 (2.4) | 3.8 (2.4) | 4.9 (2.3) | 4.5 (2.3) |
Fatiguea | 3.3 (2.6) | 3.4 (2.6) | 4.2 (2.6) | 3.8 (2.7) | 4.9 (2.6) | 4.5 (2.6) |
PGAa | 3.1 (2.3) | 3.3 (2.5) | 4.2 (2.3) | 3.8 (2.3) | 4.9 (2.3) | 4.5 (2.2) |
Tender joint count | 1.9 (3.3) | 1.9 (3.3) | 3.6 (4.9) | 3.3 (5.0) | 4.5 (5.9) | 3.8 (5.3) |
Swollen joint count | 1.3 (2.3) | 1.2 (2.5) | 2.3 (3.6) | 1.9 (3.3) | 2.5 (4.0) | 2.0 (3.5) |
% of patients | ||||||
HAQ-DI remission (≤0.5) | 52.2 | 54.2 | 24.7 | 26.2 | 8.71 | 11.1 |
DAS28 remission (≤2.6) | 46.6 | 48.7 | 25.2 | 34.8 | 17.5 | 24.4 |
DAS28-dcrit response (≥1.8 from baseline) | 66.0 | 68.4 | 50.1 | 53.5 | 32.1 | 36.2 |
Pain-dcrit response (≥3 from baseline) | 67.5 | 67.9 | 45.2 | 47.6 | 27.2 | 31.3 |
Fatigue-dcrit response (≥3 from baseline) | 59.7 | 51.9 | 38.2 | 42.5 | 23.4 | 27.9 |
PGA-dcrit response (≥3 from baseline) | 67.5 | 63.9 | 43.7 | 48.7 | 28.7 | 31.4 |