From: The challenges of gout flare reporting: mapping flares during a randomized controlled trial
No tophi, n = 77 | Tophi, n = 43 | Disease duration ≤ 12.5 yearsa, n = 63 | Disease duration > 12.5 years, n = 57 | Three or fewer flares in prior 4 months, n = 64 | More than three flares in prior 4 monthsb, n = 56 | No anti-inflammatory medications n = 38 | Anti-inflammatory medications n = 82 | ||
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Days with self-reported flare | |||||||||
Swollen joint count | r | 0.49 | 0.45 | 0.63 | 0.38 | 0.37 | 0.66 | −0.23 | 0.73 |
P | < 0.001 | 0.005 | < 0.001 | 0.004 | 0.004 | < 0.001 | 0.20 | < 0.001 | |
Tender joint count | r | 0.42 | 0.65 | 0.56 | 0.43 | 0.46 | 0.52 | −0.01 | 0.63 |
P | < 0.001 | < 0.001 | < 0.001 | 0.001 | < 0.001 | < 0.001 | 0.98 | < 0.001 | |
C-reactive protein | r | 0.19 | 0.38 | 0.16 | 0.44 | 0.13 | 0.48 | 0.28 | 0.27 |
P | 0.11 | 0.02 | 0.25 | 0.001 | 0.34 | < 0.001 | 0.12 | 0.02 | |
Patient global assessment | r | 0.67 | 0.41 | 0.61 | 0.61 | 0.53 | 0.64 | 0.57 | 0.63 |
P | < 0.001 | 0.01 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | |
Physician global assessment | r | 0.66 | 0.42 | 0.62 | 0.61 | 0.52 | 0.65 | 0.59 | 0.63 |
P | < 0.001 | 0.009 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | |
AUC pain-by-time plot | |||||||||
Swollen joint count | r | 0.48 | 0.47 | 0.68 | 0.30 | 0.41 | 0.55 | −0.19 | 0.73 |
P | < 0.001 | 0.004 | < 0.001 | 0.03 | 0.001 | < 0.001 | 0.28 | < 0.001 | |
Tender joint count | r | 0.35 | 0.60 | 0.50 | 0.40 | 0.36 | 0.54 | 0.06 | 0.51 |
P | 0.002 | < 0.001 | < 0.001 | 0.002 | 0.005 | < 0.001 | 0.73 | < 0.001 | |
C-reactive protein | r | 0.23 | 0.54 | 0.26 | 0.42 | 0.21 | 0.52 | 0.20 | 0.37 |
P | 0.06 | < 0.001 | 0.06 | 0.001 | 0.11 | < 0.001 | 0.28 | 0.001 | |
Patient global assessment | r | 0.72 | 0.46 | 0.67 | 0.67 | 0.58 | 0.65 | 0.72 | 0.64 |
P | < 0.001 | 0.004 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | |
Physician global assessment | r | 0.72 | 0.45 | 0.67 | 0.65 | 0.58 | 0.65 | 0.72 | 0.64 |
P | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |