Table 1 Demographics of SSc cases stratified by calendar time
1995–2001 | 2002–2008 | 2009–2015 | p-value | |
|---|---|---|---|---|
N | 830 | 887 | 1061 | |
Mean age | 53.7 (15.6) | 55.0 (15.3) | 56.1 (15.5) | 0.0008 |
Women | 652 (79%) | 687 (77%) | 775 (73%) | 0.01 |
Immigrants | 56 (7%) | 50 (6%) | 86 (8%) | 0.20 |
Cancer | 48 (6%) | 51 (6%) | 101 (10%) | 0.001 |
Chronic obstructive pulmonary disease | 12 (1%) | 21 (2%) | 48 (5%) | 0.0002 |
Treated hypertension (defined as at least 2 antihypertensive agents) | 132 (16%) | 264 (30%) | 471 (44%) | < 0.0001 |
Diabetes | 25 (3%) | 53 (6%) | 61 (6%) | 0.007 |
Upper gastrointestinal ulcer | 47 (6%) | 62 (7%) | 83 (8%) | 0.18 |
Renal disease | 18 (2%) | 18 (2%) | 40 (4%) | 0.03 |
Heart failure | 24 (3%) | 26 (3%) | 34 (3%) | 0.91 |
Prior acute myocardial infarction | 28 (3%) | 28 (3%) | 30 (3%) | 0.79 |
Peripheral artery disease | 34 (4%) | 34 (4%) | 53 (5%) | 0.42 |
Ischemic stroke | 13 (2%) | 23 (3%) | 33 (3%) | 0.10 |