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Table 1 Clinical information of patients with aRA, iRA, and OA and of HL

From: A proteomic analysis of serum-derived exosomes in rheumatoid arthritis

 

Active RA (n = 12)

Inactive RA (n = 11)

p Value (aRA vs. iRA)

OA (n = 10)

HL (n = 10)

Age (years), mean (range)

62.2 (31 to 79)

63.4 (41 to 80)

0.85

62.5 (41 to 74)

60.5 (41 to 82)

Sex, male/female

2/10

3/8

0.93

1/9

2/8

Disease duration (years), mean (range)

5.6 (0.25 to 20)

10.9 (0.25 to 38)

0.22

(−)

(−)

ESR (mm/h), mean (range)

56.3 (16 to 100)

21.0 (2 to 41)

< 0.01

(−)

(−)

CRP (mg/L), mean (range)

3.19 (0.07 to 7.16)

0.14 (0.02 to 0.33)

< 0.01

(−)

(−)

MMP-3 (ng/mL), mean (range)

252.0 (18.8 to 602.4)

52.7 (10 to 121.5)

< 0.01

(−)

(−)

SJC, mean (range)

3.7 (1 to 8)

0

< 0.01

(−)

(−)

TJC, mean (range)

6.3 (0 to 17)

0.8 (0 to 3)

< 0.01

(−)

(−)

RF positive (%)

83.3

72.7

0.56

(−)

(−)

ACPA positive (%)

90.0

77.8

0.49

(−)

(−)

DAS28-ESR, mean (range)

4.80 (4.21 to 5.72)

2.33 (0.51 to 3.02)

< 0.01

(−)

(−)

DAS28-CRP, mean (range)

3.84 (3.10 to 4.64)

1.49 (0.98 to 2.2)

< 0.01

(−)

(−)

Medication

 DMARDs (%)

75.0

90.9

0.34

(−)

(−)

 Methotrexate (%)

50.0

81.8

0.11

(−)

(−)

 Biologics (%)

8.0

18.1

0.51

(−)

(−)

 Prednisolone (%)

41.7

0

0.01

(−)

(−)

  1. ESR erythrocyte sedimentation rate, CRP C-reactive protein, MMP-3 matrix metalloproteinase-3, SJC swollen joint count, TJC tender joint count, RF rheumatoid factor, ACPA anti-cyclic citrullinated peptide antibody, DAS28-ESR disease activity score 28 joints using erythrocyte sedimentation rate, DAS28-CRP disease activity score 28 joints using C-reactive protein, DMARDs disease-modifying anti-rheumatic drugs