Table 3 Minimal clinically important difference in change from baseline to Week 24 by MDA responder (R) or non-responder (NR) status
Achieved MCID Improvement | MDA-R (n = 152) | MDA-NR (n = 322) | P-Value Ɣ-Value (ASE)a | Odds Ratio (95% CIs) |
|---|---|---|---|---|
SF-36 Domains | ||||
Physical functioning | ||||
Yes | 124 (81.6%) | 182 (56.5%) | <.001 | 3.41 |
No | 28 (18.4%) | 140 (43.5%) | .55 (.083) | (2.14, 5.43) |
Role physical | ||||
Yes | 124 (81.6%) | 175 (54.3%) | <.001 | 3.72 |
No | 28 (18.4%) | 147 (45.7%) | .58 (.079) | (2.34, 5.92) |
Bodily pain | ||||
Yes | 130 (85.5%) | 188 (58.4%) | <.001 | 4.21 |
No | 22 (14.5%) | 134 (41.6%) | .62 (.080) | (2.55, 6.97) |
General health | ||||
Yes | 121 (79.6%) | 166 (51.6%) | <.001 | 3.67 |
No | 31 (20.4%) | 156 (48.4%) | .57 (.077) | (2.34, 5.76) |
Vitality | ||||
Yes | 118 (77.6%) | 184 (57.1%) | <.001 | 2.60 |
No | 34 (22.4%) | 138 (42.9%) | .44 (.090) | (1.68, 4.04) |
Social functioning | ||||
Yes | 95 (62.5%) | 149 (46.3%) | <.001 | 1.94 |
No | 57 (37.5%) | 173 (53.7%) | .32 (.090) | (1.30, 2.87) |
Role emotional | ||||
Yes | 66 (43.4%) | 143 (44.4%) | .840 | .96 |
No | 86 (56.6%) | 179 (55.6%) | −.02 (.099) | (0.65, 1.42) |
Mental health | ||||
Yes | 90 (59.2%) | 166 (51.6%) | .118 | 1.36 |
No | 62 (40.8%) | 156 (48.4%) | .15 (.097) | (0.92, 2.02) |
SF-36 PCS | ||||
Yes | 130 (85.5%) | 157 (48.8%) | <.001 | 6.21 |
No | 22 (14.5%) | 165 (51.2%) | .72 (.061) | (3.76, 10.26) |
SF-36 MCS | ||||
Yes | 80 (52.6%) | 160 (49.7%) | .550 | 1.13 |
No | 72 (47.4%) | 162 (50.3%) | .06 (.098) | (0.76, 1.66) |
EQ-5D-5 L HSI | ||||
Yes | 117 (77.0%) | 152 (47.2%) | <.001 | 3.74 |
No | 35 (23.0%) | 170 (52.8%) | .58 (.074) | (2.42, 5.78) |
EQ-5D VAS | ||||
Yes | 113 (74.3%) | 130 (40.4%) | <.001 | 4.28 |
No | 39 (25.7%) | 192 (59.6%) | .62 (.067) | (2.79, 6.56) |