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Table 5 Longitudinal associations of baseline DAS28-related variables with pain at follow up

From: Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis

 

ERAN

BSRBR anti-TNF

BSRBR-Non-Biologic

Univariate

Multivariable

Univariate

Multivariable

Univariate

Multivariable

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

TJC

−0.28 (− 0.34 to − 0.22)

< 0.001

−0.09 (− 0.21 to 0.03)

0.131

−0.10 (− 0.12 to − 0.08)

< 0.001

−0.02 (− 0.05 to 0.01)

0.264

−0.23 (− 0.26 to − 0.19)

< 0.001

−0.10 (− 0.16 to − 0.05)

< 0.001

SJC

−0.09 (− 0.15 to − 0.03)

0.004

0.07 (− 0.01 to 0.16)

0.087

−0.02 (− 0.04 to 0.00)

0.090

0.03 (0.00 to 0.06)

0.029

−0.04 (− 0.08 to − 0.01)

0.019

−0.02 (− 0.07 to 0.03)

0.523

VAS-GH

−0.36 (− 0.44 to − 0.29)

< 0.001

−0.10 (− 0.23 to 0.02)

0.102

−0.14 (− 0.16 to − 0.12)

< 0.001

−0.02 (− 0.05 to 0.01)

0.139

−0.29 (− 0.32 to − 0.26)

< 0.001

−0.14 (− 0.20 to − 0.09)

< 0.001

ESR

−0.18 (− 0.25 to − 0.11)

< 0.001

0.07 (− 0.07 to 0.20)

0.338

−0.07 (− 0.09 to − 0.05)

< 0.001

0.01 (− 0.02 to 0.03)

0.695

−0.09 (− 0.13 to − 0.05)

< 0.001

−0.04 (− 0.11 to 0.04)

0.349

DAS28

−0.31 (− 0.38 to − 0.23)

< 0.001

−0.04 (− 0.17 to 0.09)

0.564

−0.14 (− 0.16 to − 0.12)

< 0.001

−0.02 (− 0.04 to 0.01)

0.176

−0.25 (− 0.28 to − 0.21)

< 0.001

−0.13 (− 0.19 to − 0.07)

< 0.001

DAS28-P

−0.26 (− 0.34 to − 0.19)

< 0.001

−0.15 (− 0.27 to − 0.04)

0.007

−0.07 (− 0.09 to − 0.05)

< 0.001

−0.02 (− 0.04 to 0.00)

0.089

−0.20 (− 0.24 to − 0.17)

< 0.001

−0.14 (− 0.23 to − 0.05)

0.002

Tender-swollen difference

−0.25 (− 0.32 to − 0.18)

< 0.001

−0.14 (− 0.24 to − 0.04)

0.004

−0.08 (− 0.10 to − 0.06)

< 0.001

−0.03 (− 0.05 to − 0.00)

0.019

−0.20 (− 0.23 to − 0.16)

< 0.001

−0.11 (− 0.17 to − 0.05)

0.001

Tender:swollen ratio

−0.17 (− 0.23 to − 0.10)

< 0.001

−0.14 (− 0.21 to 0.06)

< 0.001

−0.06 (− 0.08 to − 0.05)

< 0.001

−0.03 (− 0.05 to − 0.01)

0.007

−0.15 (− 0.19 to − 0.11)

< 0.001

−0.08 (− 0.14 to − 0.02)

0.016

  1. Generalised Estimating Equations for prediction of longitudinal pain (3/6 month and 1 year SF36-Bodily Pain). Univariate analyses show the associations between baseline DAS28-related variables and longitudinal pain with no adjustments. Multivariable analyses were similar, but with adjustments for baseline measures of pain, DAS28, CRP, seropositive, age, gender, BMI, smoking, SF36-physical function, SF36-vitality, SF36-mental health. TJC tender joint count, SJC swollen joint count, ESR erythrocyte sedimentation rate, VAS-GH visual analogue scale-general health. DAS28-P = proportion of DAS28-ESR attributable to patient-reported components. No corrects were performed for multiple comparisons. Statistically significant findings highlighted in bold