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Table 2 Genotype and allele frequency of PTPN22 gene R620W functional variant in SLE patients and controls

From: High prevalence of protein tyrosine phosphatase non-receptor N22 gene functional variant R620W in systemic lupus erythematosus patients from Kuwait: implications for disease susceptibility

Genotype/Allele

SLE patients

N = 126 (%)

Controls

N = 214 (%)

OR (95% CI)a

P-value*

CC

81 (64.3)

180 (84.1)

0.34 (0.20–0.57)

< 0.0001

CT

23 (18.3)

32 (15)

1.27 (0.70–2.28)

0.51

TT

22 (17.4)

2 (0.9)

22.42 (5.17–97.21)

< 0.0001

Distribution of Alleles

C – allele

185/252 (73.4)

392/428 (91.6)

0.25 (0.16–0.39)

< 0.0001

T – allele

67/252 (26.6)

36/428 (8.4)

3.94 (2.53–6.13)

< 0.0001

  1. aOR, odds ratio at 95% confidence interval
  2. *P-values were considered significant when < 0.05
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