Seronegative pSS (n = 40) | Seropositive pSS (n = 192) | P-value | |
---|---|---|---|
Basic characteristic | |||
Age at diagnosis (years) | 56.5 (50.00-63.75) | 48.00 (39.00–58.00) | 0.000* |
Gender (female/male) | 36/4 | 176/16 | 0.974 |
Course of disease (months) | 36 (12.00-117.00) | 24 (5.00–60.00) | 0.042* |
Clinical manifestations | |||
Xerostomia | 32/40 (80.00) | 111/192 (57.80) | 0.009* |
Xerophthalmia | 25/40 (62.50) | 86/192 (44.80) | 0.041* |
Schirmer test positivity | 24/26 (92.30) | 85/110 (77.30) | 0.084 |
Saprodontia | 7/40 (17.50) | 19/192 (9.90) | 0.266 |
Cutaneous manifestations | 3/40 (7.50) | 28/192 (14.60) | 0.231 |
Interstitial lung disease | 16/40 (42.50) | 74/183 (40.40) | 0.860 |
NSIP | 11/16 (68.75) | 65/74 (87.84) | 0.056 |
OP | 3/16 (18.75) | 8/74 (10.81) | 0.405 |
UIP | 2/16 (12.50) | 1/74 (1.35) | 0.080 |
Pulmonary arterial hypertension | 1/19 (5.30) | 3/74 (4.10) | 1.000 |
ITP | 2/40 (5.00) | 28/192 (14.60) | 0.100 |
Anemia | 13/40 (32.50) | 66/192 (34.40) | 0.820 |
Leukopenia | 4/40 (10.00) | 27/192 (14.10) | 0.492 |
Peripheral neuropathy | 1/40 (2.50) | 9/192 (4.70) | 0.848 |
Central neuropathy | 1/40 (2.50) | 6/192 (3.10) | 1.000 |
Arthropathy | 11/40 (27.50) | 35/192 (18.20) | 0.181 |
Renal interstitial disease | 0/40 (0.00) | 4/192 (2.10) | 1.000 |
Hypokalemia | 2/40 (5.00) | 30/192 (15.60) | 0.076 |
Primary biliary cirrhosis | 2/40 (5.00) | 4/192 (2.10) | 0.276 |
Infection | 12/40 (30.00) | 51/192 (26.60) | 0.657 |
ESSDAI score < 5 | 13/40 (32.50) | 30/192 (15.63) | 0.013* |
Laboratory findings | |||
Hemoglobin, g/L | 125.50 (110.25-136.75) | 123.00 (111.00-132.00) | 0.268 |
Leukocyte, X109/L | 6.32 (4.70–7.91) | 5.50 (4.14–7.28) | 0.258 |
Platelet, X109/L | 265.0 (205.25-310.75) | 218.5 (162.50-272.75) | 0.003* |
ESR, mm/h | 16.50 (11.00–54.00) | 33.00 (17.00–54.00) | 0.044* |
CRP, mg/dL | 1.00 (0.54–5.75) | 1.90 (0.61–5.80) | 0.460 |
ALT, U/L | 20.00 (14.0–32.0) | 18.00 (13.00–28.00) | 0.230 |
AST, U/L | 20.00 (15.00-32.50) | 19.00 (15.00–27.00) | 0.873 |
Serum total bilirubin, U/L | 10.85 (7.48–15.40) | 8.00 (5.90–10.90) | 0.005* |
FT3, U/L | 4.40 (3.61–4.65) | 4.27 (3.70–4.70) | 0.955 |
FT4, U/L | 14.28 (12.56–15.60) | 14.67 (12.68–16.15) | 0.521 |
TSH, U/L | 2.09 (1.41–3.27) | 2.13 (1.27–3.50) | 0.968 |
Creatine kinase, U/L | 62.00 (33.75-103.25) | 48.00 (30.00-67.75) | 0.026* |
Creatinine, umol/L | 49.5 (42.25-61.00) | 54.0 (45.0-61.25) | 0.179 |
Immunosuppressive drugs | |||
Glucocorticoid | 23/40(57.50) | 156/192(81.30) | 0.001* |
DMARDs | 35/40(87.50) | 184/192(95.80) | 0.037* |
Comorbidities | 10/40 (25.00) | 73/192 (38.00) | 0.118 |